What is the Neurostatus-EDSS?
The Neurostatus-EDSS is a scoring system, more precisely a disability status scale, used to measure the level of disability in people with multiple sclerosis (pwMS). It is based on an standardized clinical examination of functional domains, such as vision and mobility.
The Neurostatus-EDSS summarizes the assessment of seven Functional Systems (FSs) and the ambulation score (AS) in patients affected by MS or other neuroimmunological diseases. Each FS consists of a set of subscores representing either single examination tests and patient’s reported outcomes (PROs). The final EDSS step is then calculated based on the 7 FS Scores (FSS) and the AS.
The Neurostatus-EDSS was developed, standardized, and adapted from the version of J. Kurtzke’s 1983 EDSS scoring table, with the aim of further improving inter- and intra-rater reliability and consistency in assessments.
Specifically, both the performance of the neurological examination and the documentation of abnormal findings were standardised. This was achieved by providing:
By using the Neurostatus-EDSS, physicians and researchers can have greater confidence in the accuracy and reliability of their assessments, ultimately leading to a better understanding and management of MS.
How can the Neurostatus-EDSS be used in clinical or academic trials?
Use of the Neurostatus-EDSS© in a clinical or academic trial always requires a License Agreement with Neurostatus-UHB. The License Agreement provides the Sponsor with access to any Neurostatus components as required, including:
Alternatively, an electronic, algorithm-based version of the Neurostatus-EDSS (the Neurostatus-eEDSS) can be used in any clinical or academic trial.